Sunday, March 16, 2014

PREVALENCE OF ACUTE MYOCARDIAL INFARCT IN NORMOLIPIDEMIC PATIENTS


Journal Critique in Cardiovascular Risk Factors in Elderly Normolipidemic Acute Myocardial Infarct Patients in India by CINDY  ESCOBA, PEARL HARRIETTE RAMIREZ, CHARISH PUENTENEGRA and GERARDINE CAƑETE under MR. JULIUS P. MARIO Faculty of the College of Medical Technology of Southwestern University, Cebu City

The concern of the uprising cases of myocardial infarction in patients had been tremendously looked upon by the researchers to come up with valuable parameters in determining myocardial infarction. Basically, they focused on the cardiovascular risk factors which are mainly associated with the disease but monitored with normolipidemic patients. With the emphasis of coronary artery disease, various conditions have shown that lipid levels play a crucial role in dealing cases with myocardial infarction due to free radical generation and ischemia. Facts pertaining to the importance of observing high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) in the introduction had been essentially explained as well as its mechanisms involving oxidation by the antioxidant enzyme system. The objectives presented are clear enough in accordance with the study and is in parallel with the use of practical instrumentations conducive to the researchers’ benefit. The abstract directly interpreted the significant results but with lesser elucidation as to how relevant is determining the risk factors in elderly normolipidemic AMI patients.

The methodologies used in the study are well-established. The normolipidemic status is judged by several diagnostic criteria. Although there is a thorough selection of patients but there is no explanation stated as to why they come to exclude several patients with diabetes mellitus or those with renal insufficiency. There is specificity of the methods employed to every parameter but there should have been an elaboration on the method’s principle why the researchers are in favor to use it. With its wide-variety selection of tests, this study can not be easily duplicated since all chemicals are of analytical grade and are some are manufactured and obtained from other countries. The advancement of technology in their country set an edge towards their study as quantitation is concerned.

The results obtained from the various methods are presented in a tabulated manner. The tables are differentiated according to the patient’s status and other biochemical parameters in patients. Moreover, the controls used provided a solid foundation for the basis of their study. A further justification of the legends has to be revised since some of it doesn’t correspond to the table shown. The discussion points out the risk factors that can serve as markers for detecting acute myocardial infarctions. The interpretation of results was carefully evaluated by the researchers such then there were some redundancy upon the antioxidants’ mechanism involving the disease. However, recommendations are indicated as to evaluation of other inflammatory markers to be given further consideration.

The topic and the research framework are appropriate for the journal. It clearly relates to the ideas discussed in the study. The abstract presented a brief yet an accurate summary of the article that defines its purpose, methodology and the discussion. The ideas are well-designated to its corresponding paragraphs in a sense that it correlates to the results. The proponents have conveyed understanding upon the readers as well as it exhibits a clearer picture of the problem. In general, the presented research study is logical and significant.

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